In his signature red carpet pose at the Source Hip-Hop Awards in 1999

(Photo by Brenda Chase / Online USA / Liaison Agency)

In 1999 Dustin Hoffman attended Eminem's concert with his children. Hoffman later joined Em and Dre onstage and performed Dre's "Nuthin' But A 'G' Thang."

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Xzibit, Eminem and Dr. Dre in Cancun at MTV's Spring Break 2000

(Photo by Frank Micelotta/ImageDirect)

2000 MTV Video Music Awards Rehearsals

(Frank Micelotta/Getty Images)

2001 brought us an Eminem doll. Manufactured by Art Asylum, the doll even had the rapper's tattoos recreated in detail.

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His iconic performance with Elton John at the Grammy Awards in 2001

(photo by Frank Micelotta/Getty Images)

Accepting his first Grammy in 2001; for Best Rap Album.

(Photo by Kevin Winter/Getty Images)

Eminem pleads guilty to carring a concealed weapon in 2001

(Photo by MAX ORTIZ/AFP/Getty Images)

Eminem's confrontaion with Triumph the Insult Comic Dog at the 2002 VMAs!

(Photo by Scott Gries/ImageDirect)

Fans bring traffic in Times Square to a halt hoping to see Em during an appearance on TRL in 2002.

( Photo by Scott Gries/ImageDirect)

After squashing the beef, Christina Aguilera presents an award to Eminem at the 2002 MTV Video Music Awards.

(Photo by Scott Gries/ImageDirect.)

At the 8 Mile Premiere in 2002

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Eminem, 50 Cent, and Dr. Dre in 2004.

(Photo by Frank Micelotta/Getty Images)

At the 2009 VMAs onstage with GaGa. If he had only written a song about this moment...

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Em with Run DMC at the Rock & Roll Hall Of Fame Induction, 2009

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Who could forget the 2009 MTV Movie Awards where a winged Sacha Baron Cohen falls booty-up in Eminem's lap, promptly causing Em to walk out.

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The dynamic duo reunite onstage at the Grammy Awards in 2011.

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